Publication: Nestin expression in normal adrenal gland and adrenocortical tumors
Authors
Toti, P. ; Regoli, M. ; Nesi, G. ; Occhini, R. ; Bartolommei, S. ; Fonzi, L. ; Bertelli, E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Human adrenocortical cells have been shown
to express cytokeratins and vimentin. Nestin is an
intermediate filament protein that is mainly expressed in
the developing nervous system and that has been
recently reported in rat adrenal gland as well. Using
immunohistochemical and biochemical approaches, the
present study demonstrates that nestin is constantly
expressed in situ in the cortex of normal human adrenal
glands. Nestin expressing cells were prevalently located
in the zona reticularis but some positive cells could be
spotted in the zona fasciculata as well. Moreover,
patches of nestin-positive cells have been constantly
detected on sections of cortical adenomas. In contrast,
adrenal carcinomas displayed a variable number of
nestin-immunoreactive cells that in some cases were
virtually absent. Samples of renal clear cell carcinoma
metastasis in the adrenals were also examined which did
not show nestin-immunoreactivity. We propose that a
positive nestin-immunoreaction could be useful in
differential diagnosis of clear cell tumors in adrenal
glands.
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