Publication: Hypoxia-inducible factor (HIF) in human tumorigenesis
Authors
Mabjeesh, N.J. ; Amir, S.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Hypoxia is a major event that occurs in most
solid tumors. Intratumoral hypoxia is sufficient to
activate the key transcription factor, hypoxia-inducible
factor (HIF) that mediates the activation of the “survival
machinery” in cancer cells. HIF can also be induced by
oxygen-independent genetic alterations that activate a
variety of oncogenic signaling pathways or inactivate
tumor suppressors. Increased tumor HIF occurs at early
stages of carcinogeniesis and is often correlated with
increased angiogenesis, malignant progression, poor
patient prognosis and chemoradio-resistance. HIF-a
subunit, the oxygen-regulated subunit of HIF is
overexpressed in a wide range of human solid tumors.
Nuclear HIF-a protein immunostaining was restricted to
tumor cells compared to normal tissues. Herein, we
review and discuss the role of HIF in tumorigenesis and
describe the overexpression of HIF-a proteins in human
cancers and its association with overall clinical
outcomes
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.