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Contribution of the dopaminergic system in toxoplasmic encephalitis neuroimmunopathogenesis

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dc.contributor.authorAnteplıoğlu, Tuğçe
dc.contributor.authorDincel, Gungor Cagdas
dc.contributor.authorAlçiğir, Mehmet Eray
dc.contributor.authorTürkmen, Merve Bışkın
dc.contributor.authorYapic, Tilbe Su
dc.contributor.authorKul, Oguz
dc.contributor.authorAl Olayan, Ebtsam
dc.contributor.authorAlshahrani, Mohammad Y.
dc.contributor.authorEl Ashram, Saeed
dc.contributor.departmentBiología Celular e Histologíaes
dc.date.accessioned2025-07-23T07:55:35Z
dc.date.available2025-07-23T07:55:35Z
dc.date.issued2025
dc.description.abstractToxoplasma gondii (T. gondii), a parasitic intracellular protozoan, can establish a chronic infection in the host brain and cause significant neuropathology. The current study aimed to determine the role of Tyrosine Hydroxylase (TH), Dopamine Receptor D1 (D1R), Nuclear Receptor Related-1 (Nurr1), and Dopamine Transporter (DAT) expression in the neuroimmunopathogenesis of toxoplasmic encephalitis (TE) at 15, 30, 45, and 60 days after infection with T. gondii. Additionally, the study investigated whether there was a correlation between the markers on these critical days, which had yet to be explored. The results showed that TH expression in brain tissue of BALB/c mice was significantly increased in all infected groups compared with healthy controls (p<0.05). However, other striking findings of the study were that D1R, DAT, and Nurr1 expression were significantly decreased in all infected groups compared with healthy controls, in contrast to TH expression (p<0.05). Study findings regarding behavioral changes in chronic T. gondii-infected laboratory animals and humans with TE provide important evidence of the relationship between neuropsychiatric diseases and T. gondii infection. By elucidating the pathogenesis of the disease in detail, treatment protocols that consider these coordinated changes in expression that vary from day to day can be developed.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationHistology and Histopathology Vol. 40, nº08 (2025)
dc.identifier.doihttps://doi.org/10.14670/HH-18-877
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/157658
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDATes
dc.subjectD1Res
dc.subjectNurr1es
dc.subjectToxoplasma gondiies
dc.subjectTyrosine hydroxylasees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleContribution of the dopaminergic system in toxoplasmic encephalitis neuroimmunopathogenesises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.40, nº8 (2025)