Publication: Immunocytochemical localization of metabotropic
(mGluR2/3 and mGluR4a) and ionotropic (GluR2/3)
glutamate receptors in adrenal medullary ganglion cells
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Date
2006
Authors
Sarría, R. ; Díez, J. ; Losada, J. ; Doñate-Oliver, F. ; Kuhn, R. ; Grandes, P.
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Publisher
Murcia : F. Hernández
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Description
Abstract
The localization of metabotropic glutamate
receptors of groups II (mGluR2/3) and III (mGluR4a)
and the subunits 2 and 3 of alfa-amino-3-hydroxy-5-
methyl-4-isoxazolepropionic acid (AMPA) ionotropic
glutamate receptors (GluR2/3) was investigated with
immunocytochemical methods in the rat adrenal gland.
MGluR2/3, mGluR4a and GluR2/3 immunoreactivities
were observed in large-sized, centrally located type I
adrenal medullary ganglion neurons. Furthermore, the
small-sized type II adrenal ganglion neurons identified
by their immunoreactivity to brain nitric oxide synthase
(bNOS), also expressed mGluR2/3, mGluR4a and
GluR2/3. These cells were disposed in the peripheral
portion of the adrenal medulla. None of the type I
neurons were positively labeled for bNOS. These
morphological observations suggest that activation of
glutamate receptors in ganglion neurons may be
instrumental in the control of adrenal endocrine systems
as well as blood regulation.
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