Publication: Differences in collagen distribution
of healthy and regenerated periodontium.
Histomorphometric study in dogs
Authors
Souza, Sérgio Luis Scombatti de ; Macedo, Guilherme O. ; Silveira e Souza, Adriana M.M. ; Taba Jr, Mário ; Novaes Jr, Arthur B. ; Oliver, Constance ; Jamur, Maria C. ; Correa, Vani M.A.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Previous studies have shown that there is a
relationship between periodontal disease and the
distribution of collagen fibers. This study evaluated the
distribution of collagen types I and III in regenerated
bone and periodontal ligament, comparing them to the
tissues near the regenerated area and to the healthy
periodontium. In the third (P3) and fourth (P4)
mandibular premolars of 5 healthy mongrel dogs,
bilaterally, buccal class 2 furcation lesions were
surgically created and chronified for 3 weeks. After that,
full flaps were elevated and expanded polytetrafluoroethylene
(e-PTFE) membranes were adapted,
sutured and recovered by the flaps. Two weeks after
surgery, two membranes on the same side were removed
and the other membranes were removed four weeks after
surgery. The dogs were euthanized at 12 weeks
following placement of the e-PTFE membranes. P3 and
P4 teeth as well as the second premolars (healthy control
teeth) and their periodontal tissues were removed and
histologically processed for Collagen Quantification
(COLQ). The amount of type III collagen was higher in
native bone compared to the regenerated area. For
periodontal ligament, COLQ for type I collagen showed
statistically significant differences (Tukeys’s Multiple
Comparison, p<0.05) between the regenerated groups
and the control group. These differences were not found
for type III COLQ. There are significant differences in
collagen distribution among the regenerated, native and
control tissues. Membrane removal 2 or 4 weeks
postoperatively did not influence the collagen
composition.
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