Publication: Immunolocalization of antimicrobial and
cytoskeletal components in the serous
glands of human sinonasal mucosa
Authors
Stoeckelhuber, Mechthild ; Olzowy, Bernhard ; Ihler, Friedrich ; Matthias, Christoph ; Scherer, Elias Q. ; Babaryka, Gregor ; Loeffelbein, Denys J. ; Rohleder, Nils H. ; Nieberler, Markus ; Kesting, Marco R.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Secretory cells in the seromucous glands of
paranasal sinuses secrete antibacterial proteins for innate
immune mucosal integrity. We studied the localization of
antimicrobial and cytoskeletal components of the human
seromucous glands and respiratory epithelium of the
maxillary sinus and the ethmoidal cells by
immunohistochemical methods. The presence of a
variety of defense proteins such as lysozyme, lactoferrin,
cathelicidin, and defensin-1, -2, -3 point to a crucial role
in the immune defense for the respiratory tract.
Cytoskeletal proteins such as actin, myosin 2,
cytokeratin 7 and 19, α- and β-tubulin, investigated for
the first time in glands of paranasal sinuses, showed a
stronger expression at the apical and lateral cell
membrane. The localization of the cytoskeletal proteins
might point to their participation in exocrine secretory
processes and stabilizing effects.
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Citation
Histology and Histopathology, vol. 29, nº 10, (2014)
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