Publication: Signaling pathways governing osteoblast proliferation, differentiation and function
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Date
2009
Authors
Fung Ling Chau, Jenny ; Fook Leong, Wai ; Li, Baojie
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Osteoblasts are bone forming cells that are
responsible for bone growth and remodeling. They are
derived from bone marrow mesenchymal stem cells
through a series of processes including commitment,
osteoprogenitor expansion, terminal differentiation and
cell death. Osteoblastogenesis and bone formation are
regulated by hormones, growth factors, cytokines,
mechanical loading and aging. Osteoblasts can sense
these external cues, transduce the signals through
various signaling pathways and regulate the expression
of specific genes, to determine the cell fate. In this
review, we aim to update our current understanding of
the signaling pathways that control different steps of
osteoblast homeostasis, with special focus on how
signaling events control cell fate through regulating gene
expression.
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