Publication: Modulation of pulmonary neuroendocrine cells in idiopathic interstitial pneumonia
Authors
Ito, T. ; Ogura, T. ; Ogawa, N. ; Udaka, N. ; Hayashi, H. ; Inayama, Y. ; Yazawa, T. ; Kitamura, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In order to reveal modulation of the number
of pulmonary neuroendocrine cells (PNEC) in interstitial
lung diseases and to clarify significance of cell
proliferation activity in occurrence of PNEC, we counted
airway PNEC of the patients of idiopathic interstitial
pneumonia, secondary interstitial pneumonia and control
lungs, and compared the number of PNEC with airway
Ki-67 labeling. The lung tissue samples were obtained
by video-assisted thoracoscopic surgery from 22 patients
with usual interstitial pneumonia (UIP), 7 with nonspecific
interstitial pneumonia (NSIP), 8 with chronic
hypersensitivity pneumonia (CHP), 13 with collagen
vascular disease (CVD), and were compared with agematched
control lungs. The tissues were immunostained
for chromogranin A and for Ki-67. Average incidence of
bronchiolar PNEC in normal, UIP, NSIP, CHP, CVD
lungs was 0.169%, 0.348%, 0.326%, 0.175% and
0.201%, respectively, and average Ki-67 labeling index
in them was 0.241%, 1.186%, 1.605%, 1.058%, and
2.353%, respectively. And, in UIP lungs, PNEC
incidence or Ki-67 labeling index was different
according to pathological lesions. Thus, PNEC increase
in the bronchiole of UIP, and the incidence of PNEC
varies according to degree of activity of epithelial cell
proliferation probably related to epithelial cell injury.
Moreover, enhanced expression of human homolog of
achaete-scute complex (hASH1) mRNA in UIP lungs
suggests that hASH1 could play roles in the regulation
of PNEC.
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