Publication: GASC1 expression in lung carcinoma is associated with
smoking and prognosis of squamous cell carcinoma
Authors
Uimonen, Katri ; Merikallio, Heta ; Pääkkö, Paavo ; Harju, Terttu ; Mannermaa, Arto ; Palvimo, Jorma ; Kosma, Veli-Matti ; Soini, Ylermi
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
GASC1 (gene amplified in squamous cell
carcinoma 1) encodes a nuclear protein that
epigenetically catalyses the lysine demethylation of
histones.
We investigated the expression of GASC1 in
different histological subtypes of lung cancer (n=289).
Percentage value of GASC1 immunohistochemical
expression was evaluated separately in the nuclei and
cytoplasms of epithelial cancer cells. The results were
compared with clinicopathologic factors and the
smoking history of the patients.
In lung tumor cells, 38% of nuclei and 54% of the
cytoplasms stained positive for GASC1. Adenocarcinomas
expressed more GASC1 nuclear (p=0.00011)
and cytoplasmic (p=0.00074) positivity than squamous
cell carcinoma. Smokers displayed less nuclear and
cytoplasmic GASC1 expression than non-smokers
(p=0.028 and p=0.036, respectively). Similarly, patients
with more cytoplasmic positive staining had fewer pack
years (p=0.043). Nuclear GASC1 expression had an
impairing effect on survival when all histological lung
cancer types were analysed together (p=0.039) and
separately in squamous cell lung carcinoma (p=0.016).
The results reveal that GASC1 expression is higher
in adenocarcinoma than squamous cell carcinoma.
Smoking decreases GASC1 expression in tumor cells,
indicating that tobacco smoke may influence the
methylation of histone 3 lysine residues in lung cancer.
Nonetheless, nuclear GASC1 predicts a poor prognosis,
especially in squamous cell carcinoma.
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