Publication: Expression of checkpoint kinase 2 in breast carcinomas, correlation with key regulators of tumor cell proliferation, angiogenesis, and survival
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Date
2006
Authors
Ribeiro-Silva, A. ; Koyota Moutinho, M.A. ; Becker de Moura, H. ; Ribeiro do Vale, F. ; Zucoloto, S.
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Publisher
Murcia : F. Hernández
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Description
Abstract
Checkpoint kinase 2 (Chk2) is a cell-cyclecheckpoint
kinase that may act as a tumor suppressor
gene due to its important role in DNA damage signaling
and cell cycle regulation. The role of Chk2 expression in
mammary tumorigenesis, however, is still poorly
understood. This study was designed to assess the
relationship between the expression of Chk2 and wellestablished
prognostic factors, including disease-freesurvival
and overall survival; and several regulators of
cell proliferation and invasiveness in breast carcinomas,
including oncogenes, tumor suppressor genes, apoptosisrelated
proteins, and angiogenesis-related markers.
Immunohistochemistry with 27 primary antibodies was
performed in 100 formalin-fixed paraffin-embedded
samples of not otherwise specified invasive ductal
carcinomas. Clinical data were retrieved from medical
files. In normal mammary parenchyma adjacent to the
tumors Chk2 stained the nuclei of epithelial cells.
Downexpression of Chk2 protein was observed in 23
carcinomas and correlated with advanced disease.
Among the regulators of tumor cell proliferation and
invasiveness analyzed, the downexpression of Chk2 correlated only with reduced expression of p27 and
telomerase. There was no difference between the overall
survival and disease-free survival rates according to
Chk2 status. In conclusion, Chk2 correlated with
reduced expression of h-TERT and p27, but not with
angiogenic factors. Chk2 expression also did not
interfere in the outcome of the patients.
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