Publication: Epigenetic alterations in colorectal
cancer: the CpG island methylator phenotype
Authors
Bae, Jeong Mo ; Kim, Jung Ho ; Kang, Gyeong Hoon
item.page.secondaryauthor
item.page.director
Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
DNA methylation is one of the key
mechanisms of epigenetic modification, and genomewide
hypomethylation and CpG island hypermethylation
are characteristics of cancer cells. The CpG island
methylator phenotype (CIMP) is a distinctive subtype of
colorectal cancers (CRCs) that show concordant
hypermethylation of numerous promoter CpG island
loci. CIMP-positive CRCs are associated with a
proximal location in the colon, microsatellite instability,
BRAF mutation and a relatively poor clinical outcome.
CIMP-positive CRCs have their own precursor lesions,
serrated adenomas, distinct from conventional adenomas
which progress and transform into CIMP-negative
CRCs. Although the existence of CIMP-positive CRCs
is generally accepted, there has been controversy over
technical issues with gene markers, the methodology
used to define CIMP, and the prognostic or predictive
role of CIMP. This review addresses recent advances in
the field of CIMP-related research.
publication.page.subject
Citation
Histology and histopathology, Vol. 28, n.º 5 (2013)
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.