Publication: Relationships between stem cells and cancer stem cells
Authors
Crowe, D.L. ; Parsa, B. ; Sinha, U.K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Stem cells have been shown to exist in a
variety of tissues. Recent studies have characterized
stem cell gene expression patterns, phenotypes, and
potential therapeutic uses. One of the most important
properties of stem cells is that of self renewal. This
raises the possibility that some of the clinical properties
of human tumors may be due to transformed stem cells.
Similar signaling pathways may regulate self renewal in
normal and transformed stem cells. These rare
transformed stem cells may drive the process of
tumorigenesis due to their potential for self renewal.
There are important ramifications for clinical cancer
treatment if the growth of solid tumors is at least
partially dependent on a cancer stem cell population. In
the cancer stem cell model, tumor recurrence may be due
to the non-targeted stem cell compartment repopulating
the tumor. If cancer stem cells can be prospectively
identified and isolated, it should be possible to identify
therapies that will selectively target these cells.
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Citation
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