Publication: Leptin secretion by white adipose tissue and gastric mucosa
Authors
Cammisotto, P.G. ; Bendayan, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Leptin is a hormone that plays a central role
in the regulation of food intake and energy expenditure.
Originally discovered in mature white adipocytes, it was
subsequently isolated from the gastric mucosa. This
tissue contains a large number of epithelial endocrine
and exocrine cells secreting leptin in the blood stream
and in the gastric lumen, respectively. Light and electron
microscopy have shown that adipocytes and gastric
epithelial cells contain leptin along their rough
endoplasmic reticulum-Golgi-granules secretory
pathway. Both tissues synthesize a soluble form of the
leptin receptor that is secreted bound to leptin in the
blood and into the gastric juice. This soluble receptor
protect leptin and enhances its half-life. Despite the
similarities in the mechanisms of leptin secretion by
adipocytes and gastric epithelial cells, they are in fact
radically different. In gastric cells leptin follows a rapid
regulated secretion pathway whereas adipocytes secrete
leptin in a constitutive slow fashion. These differences
can be explained by the specific roles play by leptin
originating from these two different tissues. Gastric
leptin is involved in the short-term regulation of
digestion, including delay of gastric emptying,
absorption of nutrients by the intestinal wall and
secretion of gastric, intestinal and pancreatic hormones.
On the other hand, leptin secreted by white adipocytes
acts primarily on the hypothalamus for the long-term
regulation of food intake. Therefore, the coordination of adipose and gastric leptins ensures the proper
management of food processing and energy storage.
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