Publication: Clinical correlations and prognostic relevance of Fn14 expression in breast carcinoma
Authors
Wang, Jian ; Liu, Yang ; Wei, Xiao-Yi ; Wang, En-Hua
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The aim of the present study was to clarify
the expression of fibroblast growth factor-inducible 14
(Fn14), a type I transmembrane protein, in breast
carcinoma and its correlation with clinicopathological
features. We examined the expression of Fn14 in normal
breast epithelial cells as well as in breast carcinoma
cells, and in 12 cases of breast carcinoma tissues and the
paired normal breast tissues by RT-PCR and Western
blot analysis. In addition, we analyzed Fn14 protein
expression in 171 clinicopathologically characterized
breast carcinoma cases by immunohistochemistry.
Statistical analyses were applied to test for prognostic
and diagnostic associations. The results show that the
level of Fn14 mRNA and protein were higher in the
cancer cell lines and most cancer tissues than in normal
control tissues. Immunohistochemistry showed that Fn14
was expressed in 148 of 171 cases (86.5%). Statistical
analysis of cases showed that there was a significant
difference of Fn14 expression in patients categorized
according to HER-2 expression, lymph node metastasis
and clinical stage. Our results suggest that Fn14 protein
is a valuable marker of breast carcinoma progression.
Fn14 might be used as a valuable prognostic marker for
breast carcinoma patients.
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Citation
Histology and Histopathology, vol. 28, nº 7 (2013)
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