Publication: Insight into the heterogeneity of prostate
cancer through PSA-PSMA prostate
clones: mechanisms and consequences
Authors
Jemaa, Awatef Ben ; Bouraoui, Yosra ; Oueslati, Ridha
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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Description
Abstract
A major clinical challenge is posed by the
current inability to readily distinguish indolent from
aggressive tumors in prostate cancer patients. Research
efforts are dedicated to overcome this problem by
understanding the molecular basis of the transition from
normal, benign cells to prostatic intraepithelial neoplasia
(PIN), localized carcinoma, and metastatic cancer.
Combined with the evidence of the phenotypic
heterogeneity of benign prostate hyperplasia, primary
tumors and metastases, it is conceivable that several
prostate clones emerge progressively during tumor
progression. We have identified several PSA-PSMA
prostate clones during prostate cancer progression. In
this paper we focus on the susceptibilities of these PSAPSMA
prostate clones to factors that promote prostate
hyperplastic, neoplastic and metastatic development and
their consequences in disease outcome.
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Citation
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