Publication: Expression of stem cell marker CD133
in fetal and adult human kidneys and
pauci-immune crescentic glomerulonephritis
Authors
Kim, Kyungeun ; Park, Bong-Hee ; Ihm, Hyojin ; Kim, Kyung Min ; Jeong, Jinuk ; Chang, Jai Won ; Cho, Yong Mee
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Background: Different cell types in the
kidney, including those in tubules, glomeruli, and
interstitium, have been proposed as candidate adult renal
stem cells, raising controversy about the very existence
of such cells. In this study, we sought to clarify the
location and nature of adult renal stem cells and to
address their reparative role in native kidney disease.
Methods: The expression of the stem cell marker CD133
was analyzed in 31 normal fetal and adult human
kidneys by immunohistochemical methods. Co
expression of CD133 with Ki-67 and tubule specific
markers was also examined. Seventeen cases of pauciimmune
glomerulonephritis were evaluated for CD133
and Ki-67 expression, and this was correlated with the
patients’ renal prognosis. Results: CD133 was expressed
in S-shaped bodies of fetal kidneys and co-expressed
with Ki-67. It was highly expressed in mature tubules of
fetal and adult kidneys without Ki-67 co-expression.
CD133+ cells were most abundant in the S3 segment of
proximal tubules and co-expressed with the distal tubule
marker, suggesting multipotency. Most tubular CD133+
cells in normal adult kidneys exhibited pathologic
features of acute and chronic injury. In pauci-immune
glomerulonephritis, tubular CD133 and Ki-67 coexpression
tended to be higher in cases where renal
function recovered. Conclusion: These results suggest
that adult renal stem cells reside predominantly in the S3
segment of the proximal tubule, where they remain
mitotically silent under normal conditions, but can be
induced by cellular injury. These results also suggest a
potential role for adult renal stem cells in recovery from
native human kidney disease.
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