Publication: The role of junctional adhesion
molecules in cell-cell interactionsThe role of junctional adhesion
Authors
Keiper, T. ; Santoso, S. ; Nawroth, P.P. ; Orlova, V. ; Chavakis, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cell-cell-interactions are important for the
regulation of tissue integrity, the generation of barriers
between different tissues and body compartments
thereby providing an effective defence against toxic or
pathogenic agents, as well as for the regulation of
inflammatory cell recruitment. Intercellular interactions
are regulated by adhesion receptors on adjacent cells
which upon extracellular ligand binding mediate
intracellular signals. In the vasculature, neighbouring
endothelial cells interact with each other through various
adhesion molecules leading to the generation of
junctional complexes like tight junctions (TJs) and
adherens junctions (AJs) which regulate both leukocyte
endothelial interactions and paracellular permeability. In
this context, emerging evidence points to the importance
of the family of junctional adhesion molecules (JAMs),
which are localized in tight junctions of endothelial and
epithelial cells and are implicated in the regulation of
both leukocyte extravasation as well as junction
formation and permeability.
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Citation
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