Publication: Structural and ultrastructural hepatic changes in experimental canine leishmaniasis
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Date
1988
Authors
González, J.L. ; Rollán, E. ; Novoa, C. ; Castaño, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Six 4 month-old beagles were inoculated with
Leishmania donovani infantum, three of them
intraperitoneally (Group A) and the other three
intravenously (Group B). The animals from Group A
were killed 109, 433 and 592 days after inoculation and
animals from Group B 109, 171 and 334 after
inoculation. The liver of each of them was examined by
means of light and electron microscopy. The lesions
observed in both groups were very similar, but
developed more rapidly in Group B. A chronic hepatitis
appeared due to infection, characterized by the presence
of multiple intralobular granulomas and portal
inflammatory infiltrates consisting of lymphocytes,
plasmocytes and macrophages with a variable number of
amastigotes. The Kupffer cells were hyperplastic and
contained parasites in their cytoplasm. Gradually the
hepatocytes developed a progressive cellular swelling.
which during the end-stages of the process showed itself
with severe nuclear degeneration, disintegration of
cytoplasmic organelles, enlargement of the cytoplasmic
matrix and disruption of the plasma membranes, leading
to cytolysis.
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