Publication: The possible role of the gut neuroendocrine system in diabetes gastroenteropathy
Authors
El-Salhy, M.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Gastrointestinal symptoms such as nausea
and vomiting, heartburn, abdominal pain, diarrhoea,
constipation and faecal incontinence are common in
patients with diabetes. Diabetes gastroenteropathy is a
clinically relevant problem. In addition to the increased
morbidity it causes, it results in severely impaired
metabolic control, which in turn increases the risk of
hyper-/hypoglycaemia. Moreover, the poorly controlled
blood glucose level increases the risk of secondary
diabetes complications, namely, retinopathy,
nephropathy, neuropathy and cardiovascular affection.
Gastrointestinal symptoms may also cause malnutrition
in patients with diabetes, which, together with the
disturbed immune defence in diabetes, may cause
intercurrent infections. Gastrointestinal symptoms in
patients with diabetes are attributed to disturbed
gastrointestinal motility. Gastrointestinal dysmotility in
diabetes is believed to be caused by autonomic
neuropathy and/or hyperglycaemia. The neuroendocrine
system of the gut secretes peptides/amines that play an
important role in regulating gastrointestinal motility. It is
conceivable, therefore, to assume that a disturbance in
this regulatory system may contribute to the
pathogenesis of gastrointestinal complications in
diabetes. The present review gives an updated overview
of the abnormalities in the gastrointestinal neuroendocrine system in diabetes, speculates upon the
possible role of these abnormalities in the pathogenesis
of diabetes gastroenteropathy and, finally, predicts the
possible clinical implications of these findings.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.