Publication: When intracellular pathogens invade the frontiers of cell biology and immunology
Authors
Pizarro-Cerdá, J. ; Moreno, E. ; Desjardins, M. ; Gorvel, J.P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cellular microbiology has recently been
described as a new discipline emerging at the interface
between cell biology and rnicrobiology (Cossart et al.,
1996). Many microbial pathogens can enter eukaryotic
cells and live intracellularly either inside vacuoles or in
the cytoplasm. The different steps during the invasion
process are on the way of being dissected at the
molecular leve1 revealing new insights in basic cellular
functions. Indeed, bacterial pathogenesis can help us to
better understand the dynamics of cell cytoskeleton,
intracellular membrane traffic and signal transduction
events. The recent advancements in the field of microbial
pathogenesis are creating a new cross-taik between cell
biologists, microbiologists and immuno-logists. In this
review, the different strategies used by several pathogens
are presented and the mechanisms elaborated by host
cells from the immune system to eliminate the parasites
discussed.
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Citation
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