Publication: EPH receptors in cancer
Authors
Castaño, Julio ; Davalos, Verónica ; Schwartz Jr., Simo ; Arango, Diego
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
EPH receptors and their ephrin ligands
constitute the largest sub-family of receptor tyrosine
kinases (RTKs) and are components of cell signaling
pathways involved in animal development. The ability of
the EPH/ephrin guidance system to position cells and
modulate cell morphology underlies their various roles
in development. In addition, EPH signaling plays an
important role in oncogenic processes observed in
several organs. These receptors are involved in a wide
range of processes directly related with tumorigenesis
and metastasis, including cell attachment and shape,
migration, and angiogenesis. Accordingly, deregulation
of EPH expression and signaling activity could be
crucial for the tumorigenic process. This review focuses
on EPH receptors’ roles in oncogenic transformation and
tumor progression.
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