Publication: Histochemical detection of expression of binding sites for labelled hyaluronic acid and carrier-immobilized synthetic (histo-blood
group trisaccharides) or biochemically purified
(ganglioside GM1) glycoligands in nasal polyps
and other human lesions including neoplasms
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Date
1996
Authors
Hassid, S. ; Salmon, I. ; Bovin, N.V. ; Kiss, R. ; Gabius, H.J. ; Danguy, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This study is intended to demonstrate the
versatility and feasibility of custom-made oligosaccharide-
exposing neoglycoconjugates including
histo-blood group epitopes in various human lesions,
including nasal polyps. The binding of the biotinylated
probes was determined on formalin-fixed paraffinembedded
sections from archive materials. The general
aspects of our results may be interpreted as follows: the
neoglycoconjugates used here can readily detect
differences in the ability of cells to bind glycan residues
in tissue sections, thereby enabling the extent of the
binding capacity of various types of human lesions to be
compared. Furthermore, the reactivity to glycan may
reflect characteristics of the cells and their environment.
The investigation into pathological disorders with
respect to the binding capacity of these carrierimmobilized
mono- or oligosaccharide structures
derived from custom-made synthesis or biochemical
purification is based on the prospect of translating
progress in this field into the establishment of potentially
beneficial procedures for medical diagnosis and
pathological classification.
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Citation
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