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Lymph node or lymphoid aggregate? Impact on cancer resection quality, clinical prognosis, and tumor staging

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dc.contributor.authorGocht, Andreas
dc.contributor.authorWatermann, Christian
dc.contributor.authorMelzer, Madelaine
dc.contributor.authorSchumacher, Udo
dc.date.accessioned2025-01-15T15:56:13Z
dc.date.available2025-01-15T15:56:13Z
dc.date.issued2025
dc.description.abstractThe clinical outcome of most cancer patients depends on the stage of the primary tumor, the lymph node status, and if distant metastases are present. According to the Union for International Cancer Control (UICC) and the American Joint Committee on Cancer (AJCC), the Tumor Node Metastasis (TNM) classifi-cation of malignant tumors requires the examination of a minimum number of regional lymph nodes for each type of cancer to fulfill the criteria of high-quality surgical oncology. Due to the daily challenge of collecting an appropriate number of lymph nodes and time constraints when processing and assessing tissue samples, pathologists may be tempted to identify every histological lymphoid structure mimicking a lymph node as a “true” lymph node. Faced with this issue, we propose to resolve it by specifying histological characteristics to differentiate lymphoid aggregates from “true” lymph nodes. To find a minimum consensus, we suggest defining as lymph nodes only those lymphoid structures composed of lymphoid cells encapsulated by a complete or incomplete fibrous capsule.es
dc.formatapplication/pdfes
dc.format.extent14es
dc.identifier.doihttps://doi.org/10.14670/HH-18-760
dc.identifier.eisbnHistology and Histopathology Vol. 40, nº02 (2025)es
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/148498
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectLymph nodees
dc.subjectNormal tissuees
dc.subjectQuality of pathologyes
dc.subjectQuality managementes
dc.subjectHistologyes
dc.subjectStandard protocoles
dc.subjectOncologyes
dc.subjectLymphoid aggregatees
dc.subjectTumor depositses
dc.subjectTumor satelliteses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleLymph node or lymphoid aggregate? Impact on cancer resection quality, clinical prognosis, and tumor staginges
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.40, nº2 (2025)