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Bueno García, Juan Manuel

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Bueno García
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Juan Manuel
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Bueno García, Juan Manuel

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Author: Martínez-Ojeda, Rosa M. ×

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    Fluorescent bicolour sensor for low-background neutrinoless double β decay experiments
    (Nature Research, 2020-06-22) Rivilla, Iván; Aparicio, Borja; Bueno García, Juan Manuel; Casanova, David; Tonnelé, Claire; Freixa, Zoraida; Herrero, Pablo; Rogero, Celia; Miranda, José I.; Martínez-Ojeda, Rosa M.; Monrabal, Francesc; Olave, Beñat; Schäfer, Thomas; Artal, Pablo; Nygren, David; Cossío, Fernando P.; Gómez-Cadenas, Juan J.; Física
    Observation of the neutrinoless double β decay is the only practical way to establish that neutrinos are their own antiparticles1. Because of the small masses of neutrinos, the lifetime of neutrinoless double β decay is expected to be at least ten orders of magnitude greater than the typical lifetimes of natural radioactive chains, which can mimic the experimental signature of neutrinoless double β decay2. The most robust identification of neutrinoless double β decay requires the definition of a signature signal—such as the observation of the daughter atom in the decay—that cannot be generated by radioactive backgrounds, as well as excellent energy resolution. In particular, the neutrinoless double β decay of 136Xe could be established by detecting the daughter atom, 136Ba2+, in its doubly ionized state3–8. Here we demonstrate an important step towards a ‘barium-tagging’ experiment, which identifies double β decay through the detection of a single Ba2+ ion. We propose a fluorescent bicolour indicator as the core of a sensor that can detect single Ba2+ ions in a high-pressure xenon gas detector. In a sensor made of a monolayer of such indicators, the Ba2+ dication would be captured by one of the molecules and generate a Ba2+-coordinated species with distinct photophysical properties. The presence of such a single Ba2+-coordinated indicator would be revealed by its response to repeated interrogation with a laser system, enabling the development of a sensor able to detect single Ba2+ ions in high-pressure xenon gas detectors for barium-tagging experiments.
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    Quantitative structural organization of the sclera in chicks after deprivation myopia measured with second harmonic generation microscopy
    (Frontiers Media, 2024-10-22) Bueno García, Juan Manuel; Martínez-Ojeda, Rosa M.; Fernández, Enrique J.; Feldkaemper, Marita; Física
    Visual deprivation causes enhanced eye growth and the development of myopia, which is associated with a change in the arrangement of collagen fibers within the sclera. A second harmonic generation (SHG) microscope has been used to image the collagen fibers of unstained scleral punches from the posterior part of chicken eyes. We aimed to analyze the fibrous scleral tissue and quantify the changes in collagen organization in relation to the extent of induced deprivation myopia. The scleral architecture was assessed with the Radon transform (RT) through the parameter called structural dispersion (SD) that provides an objective tool to quantify the level of organization of the collagen network. We found that final refraction and axial length changes were linearly correlated. However, no significant differences in scleral thickness were found for different amounts of induced myopia. In contrast, a significant correlation between SD and refraction was demonstrated, ranging from a non-organized (in the control sclerae) to a quasi-aligned distribution (with a dominant direction of the fibers, in the sclera of myopic chicks). These findings demonstrate a remodeling process of the scleral collagen associated with myopia progression that can be measured accurately combining SHG imaging microscopy and RT algorithms.
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