Person: Razi, Syed Sibtay
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Name
Razi, Syed Sibtay
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Universidad de Murcia. Departamento de Química Orgánica
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Post-Synthetic Modifications of Amide-Enaminone-Based [2]Rotaxanes for the Stereocontrolled Synthesis of Functionalized β-Lactams
Novel amido-enaminone threads serve as efficient templates for the assembly of hydrogen-bonded [2]rotaxanes, enabling versatile post-synthetic modifications. Benzyl groups on the amido moiety allow for diastereoselective intramolecular cyclizations, yielding interlocked β-lactams. The enaminone motif makes possible the stopper exchange while preserving the mechanical bond. Combining cyclization with one-pot stopper exchange and dethreading enables the stereoselective synthesis of highly functionalized non-interlocked lactams featuring a second heterocycle at their side chain via reactions with hydrazines or hydroxylamine
Publication
Open Access
Dataset used for the article: Post-Synthetic Modifications of Amide-Enaminone-Based [2]Rotaxanes for the Stereocontrolled Synthesis of Functionalized β-Lactams
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