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10.14670/HH-11-637
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Título: | The clinical translational potential of p53-related alterations as cancer biomarkers |
Fecha de publicación: | 2015 |
Editorial: | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, vol. 30, nº 10, (2015) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | p53 Meta-analysis Cancer biomarker |
Resumen: | We aimed to analyse and summarise the potential value of the clinical use of p53-related alterations as cancer biomarkers. A systematic search and collection of the published meta-analyses on p53- related alterations and cancers in the past 5 years was conducted through appropriate queries in the PubMed database. We then composed “grey-scale” tables to show the significant levels for each variant, and the potential heterogeneity was subsequently discussed. The data show that p53-related alterations are extremely complex biomarkers in terms of their clinical translation. Together with the experimental studies on p53-related alterations, a gold-standard approach is still in need of development, with more evidence from clinical studies with large, prospectively planned cohorts, to fully understand its potential as a cancer biomarker. |
Autor/es principal/es: | Xiao, Meng Wang, Xu Chen, Wantao |
URI: | http://hdl.handle.net/10201/99969 |
DOI: | 10.14670/HH-11-637 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 18 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International |
Aparece en las colecciones: | Vol.30,nº10 (2015) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Xiao-30-1171-1183-2015.pdf | 875,22 kB | Adobe PDF | Visualizar/Abrir |
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