Por favor, use este identificador para citar o enlazar este ítem: 10.14670/HH-30.715

Registro completo de metadatos
Campo DCValorLengua/Idioma
dc.contributor.authorJarzabek, Katarzyna-
dc.contributor.authorKoda, Mariusz-
dc.contributor.authorKozlowski, Leszek-
dc.contributor.authorMilewski, Robert-
dc.contributor.authorWolczynsk, Slawomir-
dc.date.accessioned2020-09-18T10:58:40Z-
dc.date.available2020-09-18T10:58:40Z-
dc.date.issued2015-
dc.identifier.citationHistology and Histopathology, vol. 30, nº 6, (2015)es
dc.identifier.issn1699-5848-
dc.identifier.urihttp://hdl.handle.net/10201/96141-
dc.description.abstractRecent studies have raised doubts about the protective role of KiSS1/KiSS1R in breast malignancy progression. However, the role of the KiSS1/KiSS1R system in primary breast cancer remains largely unknown. The aim of the present study was to characterize the biology and invasiveness potential of primary breast cancer through evaluation of KiSS1/KiSS1R protein expression and cellular localization with regard to lymph node metastasis status, receptor status (ERs, PR and HER-2/neu), and expression of aromatase, MMP-9, Ki-67 and Cyclin D1 in primary invasive breast cancer tissues. We showed increased protein expression of both KiSS1/KiSS1R and MMP-9 in the cancerous tissue compared with noncancerous tissue adjacent to the breast tumour. In the studied group of breast cancer samples, we observed a positive correlation between KiSS1 and MMP-9. We also showed a positive correlation between KiSS1R and aromatase expression in all studied breast cancers. We did not notice any associations between the KiSS1/KiSS1R system and cell cycle regulators. KiSS1/KiSS1R did not correlate either with Cyclin D1 and Ki-67 or with receptor status. However, we showed higher levels of KiSS1R expression in ERα-negative cases than in ERα-positive cases in patients with lymph node metastasis. Present data do not confirm the protective role of KiSS1/KiSS1Rin breast cancer progression, but our results do support the hypothesis that the KiSS1/KiSS1R system is activated even in primary breast cancer and sustained during invasion to local lymph nodes.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectKiSS1/KiSS1Res
dc.subjectMMP-9es
dc.subjectPrimary breast canceres
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleImmunohistochemical study of KiSS1 and KiSS1R expression in human primary breast cancer: Association with breast cancer receptor status, proliferation markers and clinicopathological featureses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.14670/HH-30.715-
Aparece en las colecciones:Vol.30, nº6 (2015)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Jarzabek-30-715-723-2015.pdf5,35 MBAdobe PDFVista previa
Visualizar/Abrir


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons