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10.14670/HH-30.673
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Título: | Carcinosarcomas: tumors in transition? |
Fecha de publicación: | 2015 |
Editorial: | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, vol. 30, nº 6, (2015) |
ISSN: | 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Epithelial-mesenchymal transition Mesenchymal-epithelial transition Sarcomatoid carcinoma EMT MET |
Resumen: | Carcinosarcomas are rare, biphasic tumors that are comprised of carcinomatous and sarcomatous elements. While the exact mechanism by which these two phenotypes arise within a single tumor remains unclear, molecular evidence indicates that the epitheliod and spindle-cell components share a clonal origin. We propose that the biphasic nature of these neoplasms may represent an extreme case of epithelial plasticity, in which an epithelial-like cell undergoes a transition to a more mesenchymal phenotype. The present review will discuss both the histological and molecular biological evidence of the involvement of epithelial plasticity in driving the mixed phenotypes observed in carcinosarcomas. |
Autor/es principal/es: | Somarelli, Jason A. Boss, Mary-Keara Epstein, Jonathan I. Armstrong, Andrew J. Garcia-Blanco, Mariano A. |
URI: | http://hdl.handle.net/10201/96121 |
DOI: | 10.14670/HH-30.673 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 15 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International |
Aparece en las colecciones: | Vol.30, nº6 (2015) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Somarelli-30-673-687-2015.pdf | 3,82 MB | Adobe PDF | Visualizar/Abrir |
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