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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Li, W. | - |
dc.contributor.author | She, H. | - |
dc.date.accessioned | 2020-07-23T13:41:08Z | - |
dc.date.available | 2020-07-23T13:41:08Z | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Histology and Histopathology, Vol. 15, n.º 3 (2000) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/95185 | - |
dc.description.abstract | SH2 and SH3 adapter proteins connect cell surface tyrosine kinases to intracellular signaling networks. For instance, the SH3-SH2-SH3 adapter Grb2 links receptor tyrosine kinases to the Ras pathway. Nck, composed of three SH3 domains and one SH2 domain, represents a two-gene (alpha and beta) family in mammals. Ncka and Nck13 are expressed in the same cells and appear to have distinct signaling specificity. Studies show that Nck plays a role in cell mitogenesis and morphogenesis. The former uses Ras-dependent and Ras-independent pathways. The latter appears to coordinate with the Cdc42/Rac>PAK lIWASp>actin cytoskeleton pathway. Understanding the specificity of Ncka and NckB signal transduction will provide answers for the previously often conflicting observations. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Src-homology domains | es |
dc.subject | Adapters | es |
dc.subject | Tyrosine kinases | es |
dc.subject | Signal transduction | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología | es |
dc.title | The SH2 and SH3 adapter Nck: a two-gene family and a linker between tyrosine kinases and multiple signaling networks | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.15, nº 3 (2000) |
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