Por favor, use este identificador para citar o enlazar este ítem:
0213-3911
Twittear
Título: | IL-8 expression in malignant melanoma: implications in growth and metastasis |
Fecha de publicación: | 2000 |
Editorial: | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol. 15, n.º 3 (2000) |
ISSN: | 1699-5848 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología |
Palabras clave: | IL-8 Melanoma Metastasis |
Resumen: | This review article has described briefly studies supporting the concept that IL-8 expression and its regulation by inflammatory cytokines like IL-l may play an important role in controlling the phenotypes associated with melanoma progression and metastasis. It is clear from the experiments presented here that IL-8 is an important autocrine multifunctional cytokine that modulates melanoma/cell proliferation, migration by induction of extracellular matrix degradation enzymes and induces neovascularization, all of which are critical for melanoma growth and metastasis. In addition, their expression in melanoma tumor specimens suggests an association between IL-8 expression and tumor aggressiveness. Further, inflammatory cytokines produced by either tumor cells or stromal cells may regulate IL-8 expression, which can control melanoma growth and enhance our current knowledge regarding melanoma progression and metastasis. U nderstandi ng these events and their significance will allow us to design novel therapeutic approaches for treatment of melanoma. |
Autor/es principal/es: | Singh, R. K. Varney, M. L. |
URI: | http://hdl.handle.net/10201/95167 |
DOI: | 0213-3911 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 7 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International |
Aparece en las colecciones: | Vol.15, nº 3 (2000) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
IL-8 expression in malignant melanoma, implications in growth and metastasis.pdf | 5,22 MB | Adobe PDF | Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons