Please use this identifier to cite or link to this item: https://doi.org/10.14670/HH-29.1423

Title: Effect of prior exercise training and myocardial infarction-induced heart failure on the neuronal and glial densities and the GFAP-immunoreactivity in the posterodorsal medial amygdala of rats
Issue Date: 2014
Publisher: F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
Citation: Histology and Histopathology, Vol. 29, n.º 11 (2014)
ISSN: 0213-3911
1699-5848
Related subjects: CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología
Keywords: Extended amygdala
Optical fractionator
Cellular density
Astrocytic cytoskeleton
Abstract: Exercise training has neuroprotective effects whereas myocardial infarction (MI) and heart failure (HF) can cause neuronal death and reactive gliosis in the whole amygdala. The posterodorsal medial amygdala (MePD) is involved with cardiovascular reflexes and the central control of sympathetic/parasympathetic responses. Our aim was to study the effects of prior exercise training and of MI-induced HF on the neuronal and glial densities and the glial fibrillary acidic proteinimmunoreactivity (GFAP-ir) in the MePD of adult male rats. Animals (n=5/group) were: control, sedentary submitted to a sham MI (Sed Sham), sedentary submitted to MI/HF (Sed HF), trained on a treadmill and submitted to a sham MI (T Sham) or trained on a treadmill and submitted to MI/HF (T HF). The number of neurons and glial cells in the MePD was estimated using the optical fractionator and the GFAP-ir was quantified by optical densitometry. In the respective groups, treadmill training improved physical performance and MI damaged near 40% of the left ventricle. There was a hemispheric lateralization effect on the density of neurons (higher in the right MePD), but no significant difference in either the neuronal or the glial densities due to experimental condition. Regional GFAP-ir results revealed that the Sed HF group had a higher expression in the left MePD compared to the control and the Sed Sham rats (p<0.01). The present data did not evidence the effects of training or MI/HF in the MePD cellular density, but indicate a possible local restructuring of astrocytic cytoskeleton after MI/HF in rats.
Primary author: Salazar, Ana Paula S.
Quagliotto, Edson
Alves, Jadson
Oliveira, Fernando A.
Saur, Lisiani
Xavier, Léder L.
Pagnussat, Aline S.
Rasia-Filho, Alberto
URI: http://hdl.handle.net/10201/77269
DOI: https://doi.org/10.14670/HH-29.1423
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 13
Rights: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 International
Appears in Collections:Vol.29, nº11 (2014)

Files in This Item:
File Description SizeFormat 
Salazar-29-1423-1435-2014.pdf2,17 MBAdobe PDFThumbnail
View/Open


This item is licensed under a Creative Commons License Creative Commons