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Título: | Osteopontin expression and localization of Ca2+ deposits in early stages of osteoarthritis in a rat model |
Fecha de publicación: | 2014 |
Editorial: | F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol. 29, nº 7 (2014) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Osteoarthritis Articular Cartilage Ossification Osteopontin |
Resumen: | Calcium deposits have been related to articular cartilage (AC) degeneration and have been observed in late stages of osteoarthritis (OA). However, the role of those deposits, whether they induce the OA pathogenesis or they appear as a consequence of such process, is still unknown. In this work, we present the kinetics of expression and tissue localisation of osteopontin (OPN), a mineralisation biomarker, and calcium deposits in samples from (normal, sham) and osteoarthritic cartilage (in a rat model). Immunohisto-chemical and Western blot assays for OPN, as well as Alizarin red staining for calcium deposits were performed; superficial, middle, and deep zones of AC were analysed. An increased expression of OPN and calcium deposits was found in the osteoarthritic cartilage compared with that of control groups, particularly in the superficial zone of AC in early stages of OA. In addition, the expression and localisation of OPN and calcium deposits during the OA pathogenesis suggest that the pathological AC mineralisation starts in the superficial zone during OA pathogenesis. |
Autor/es principal/es: | Martínez Calleja, América Velasquillo, Cristina Vega López, Marco A. Arellano Jiménez, M. Josefina Tsutsumi Fujiyoshi, Victor K. Mondragón Flores, Ricardo Kouri Flores, Juan B. |
URI: | http://hdl.handle.net/10201/72093 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International |
Aparece en las colecciones: | Vol.29, nº 7 (2014) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Martinez-Calleja-29-925-933-2014.pdf | 6,48 MB | Adobe PDF | Visualizar/Abrir |
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