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dc.contributor.authorMartínez Calleja, América-
dc.contributor.authorVelasquillo, Cristina-
dc.contributor.authorVega López, Marco A.-
dc.contributor.authorArellano Jiménez, M. Josefina-
dc.contributor.authorTsutsumi Fujiyoshi, Victor K.-
dc.contributor.authorMondragón Flores, Ricardo-
dc.contributor.authorKouri Flores, Juan B.-
dc.identifier.citationHistology and Histopathology, Vol. 29, nº 7 (2014)es_ES
dc.description.abstractCalcium deposits have been related to articular cartilage (AC) degeneration and have been observed in late stages of osteoarthritis (OA). However, the role of those deposits, whether they induce the OA pathogenesis or they appear as a consequence of such process, is still unknown. In this work, we present the kinetics of expression and tissue localisation of osteopontin (OPN), a mineralisation biomarker, and calcium deposits in samples from (normal, sham) and osteoarthritic cartilage (in a rat model). Immunohisto-chemical and Western blot assays for OPN, as well as Alizarin red staining for calcium deposits were performed; superficial, middle, and deep zones of AC were analysed. An increased expression of OPN and calcium deposits was found in the osteoarthritic cartilage compared with that of control groups, particularly in the superficial zone of AC in early stages of OA. In addition, the expression and localisation of OPN and calcium deposits during the OA pathogenesis suggest that the pathological AC mineralisation starts in the superficial zone during OA pathogenesis.es_ES
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.subjectArticular Cartilagees_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes_ES
dc.titleOsteopontin expression and localization of Ca2+ deposits in early stages of osteoarthritis in a rat modeles_ES
Appears in Collections:Vol.29, nº 7 (2014)

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