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Título: | Significance of the tumor protease cathepsin D for the biology of breast cancer |
Fecha de publicación: | 2014 |
Editorial: | F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, vol.29, nº 4, (2014) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Breast cancer Cathepsin D Tumor marker |
Resumen: | Cathepsin D is a protease involved in the metastasis and angiogenesis of mammary carcinomas. This review analyzes the significance of the tumor protease cathepsin D in mammary carcinomas as a tumor marker. We present a systematic overview based on a selective Medline search. Cathepsin D is expressed in mammary carcinomas and exhibits higher expression in invasive ductal carcinomas compared with lobular carcinomas. Nodal positive carcinomas showed reduced cathepsin D expression compared to lymph node metastases, and increased expression has been observed in hormone-receptor negative tumors. Thus, the expression of cathepsin varies between the two histological types. Increased cathepsin D expression in acinar affection has also been described. The lack of an association of cathepsin D with known prognostic factors such as CA15-3, ERalpha and ERbeta does not prevent it from being used as a tumor marker. Cathepsin has already been used along with other genes as a prognostic parameter for carcinoma patients in gene arrays. Histol Histopathol 29, 433-438 (2014) |
Autor/es principal/es: | Dian, Darius Heublein, Sabine Wiest, Irmi Barthell, Lisa Friese, Klaus Jeschke, Udo |
URI: | http://hdl.handle.net/10201/67840 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 5 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.29, nº 4 (2014) |
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Dian-29-433-438-2014.pdf | 115,6 kB | Adobe PDF | Visualizar/Abrir |
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