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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Dian, Darius | - |
dc.contributor.author | Heublein, Sabine | - |
dc.contributor.author | Wiest, Irmi | - |
dc.contributor.author | Barthell, Lisa | - |
dc.contributor.author | Friese, Klaus | - |
dc.contributor.author | Jeschke, Udo | - |
dc.date.accessioned | 2019-02-26T12:05:00Z | - |
dc.date.available | 2019-02-26T12:05:00Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Histology and Histopathology, vol.29, nº 4, (2014) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/67840 | - |
dc.description.abstract | Cathepsin D is a protease involved in the metastasis and angiogenesis of mammary carcinomas. This review analyzes the significance of the tumor protease cathepsin D in mammary carcinomas as a tumor marker. We present a systematic overview based on a selective Medline search. Cathepsin D is expressed in mammary carcinomas and exhibits higher expression in invasive ductal carcinomas compared with lobular carcinomas. Nodal positive carcinomas showed reduced cathepsin D expression compared to lymph node metastases, and increased expression has been observed in hormone-receptor negative tumors. Thus, the expression of cathepsin varies between the two histological types. Increased cathepsin D expression in acinar affection has also been described. The lack of an association of cathepsin D with known prognostic factors such as CA15-3, ERalpha and ERbeta does not prevent it from being used as a tumor marker. Cathepsin has already been used along with other genes as a prognostic parameter for carcinoma patients in gene arrays. Histol Histopathol 29, 433-438 (2014) | es |
dc.format | application/pdf | es |
dc.format.extent | 5 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Breast cancer | es |
dc.subject | Cathepsin D | es |
dc.subject | Tumor marker | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Significance of the tumor protease cathepsin D for the biology of breast cancer | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.29, nº 4 (2014) |
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Dian-29-433-438-2014.pdf | 115,6 kB | Adobe PDF | Visualizar/Abrir |
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