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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Lin, Sheng-Li | - |
dc.contributor.author | Tu, Bin-Bin | - |
dc.contributor.author | Du, Xiao-Guo | - |
dc.contributor.author | Yan, Li-Ying | - |
dc.contributor.author | Qiao, Jie | - |
dc.date.accessioned | 2018-10-04T14:14:35Z | - |
dc.date.available | 2018-10-04T14:14:35Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Histology and Histopathology, vol. 28, nº 11 (2013) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/61620 | - |
dc.description.abstract | Objective: To explore the expression change of ER-α36 in endometria of PCOS patients. Methods: Proliferative endometria were collected and divided into three groups: CE group (n=30), proliferative endometria from control women; PCOSE group (n=30), proliferative endometria from PCOS patients; HPCOSE group (n=15), hyperplastic endometria from PCOS patients. The cellular localization of ER-α36 and ER-α66 was analyzed by immunohistochemistry, and expression of ER-α36 and ER-α66 was determined by immunohistochemistry and Real-Time Quantitative PCR. The correlation between serum hormone concentration and expression of ER-α36 and ER-α66 was analyzed. Results: ER-α36 was localized on the cell surface, cytoplasm and nucleus of glandular epithelial cells of both CE and PCOSE groups, mainly on the cell surface, and ER-α66 was localized on the nucleus. The protein and mRNA expression of ER-α36 was decreased from CE, PCOSE to HPCOSE group, while expression of ERα66 showed no obvious difference among groups. The expression ratio of ER-α36 to ER-α66 of CE, PCOSE and HPCOSE group showed a decreasing tendency. The expression of ER-α36 and its expressive ratio to ER-α66 was negatively correlated with serum concentration of LH, LH/FSH, testosterone and androstenedione. Conclusions: Lower expression of ER-α36 is associated with the development of endometrial hyperplasia in PCOS patients. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Polycystic ovary syndrome | es |
dc.subject | Estrogen receptor-α36 | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología | es |
dc.title | Lower expression of ER-α36 is associated with the development of endometrial hyperplasia in PCOS patients | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.28, nº11 (2013) |
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Lin-28-1491-1498-2013.pdf | 3,69 MB | Adobe PDF | Visualizar/Abrir |
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