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|Title:||The effect of low and high plasma levels of insulin-like growth factor-1 (IGF-1) on the morphology of major organs: studies of Laron dwarf and bovine growth hormone transgenic (bGHTg) mice|
|Publisher:||F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología|
|Citation:||Histology and Histopathology, vol. 28, nº 10 (2013)|
|Related subjects:||CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología|
Brown adipose tissue
|Abstract:||It is well known that somatotrophic/insulin signaling affects lifespan in experimental animals. To study the effects of insulin-like growth factor-1 (IGF-1) plasma level on the morphology of major organs, we analyzed lung, heart, liver, kidney, bone marrow, and spleen isolated from 2-year-old growth hormone receptor knockout (GHR-KO) Laron dwarf mice (with low circulating plasma levels of IGF-1) and 6-month-old bovine growth hormone transgenic (bGHTg) mice (with high circulating plasma levels of IGF-1). The ages of the two mutant strains employed in our studies were selected based on their overall ~50% survival (Laron dwarf mice live up to ~4 years and bGHTg mice up to ~1 year). Morphological analysis of the organs of long-living 2-year-old Laron dwarf mice revealed a lower biological age for their organs compared with normal littermates, with more brown adipose tissue (BAT) surrounding the main body organs, lower levels of steatosis in liver, and a lower incidence of leukocyte infiltration in different organs. By contrast, the organs of 6-month-old, short-living bGHTg mice displayed several abnormalities in liver and kidney and a reduced content of BAT around vital organs.|
|Primary author:||Piotrowska, Katarzyna|
Borkowska, Sylwia J.
Havens, Aaron M.
Kopchick, John J.
Taichman, Russel S.
Ratajczak, Mariusz Z.
|Number of pages / Extensions:||12|
|Appears in Collections:||Vol.28, nº10 (2013)|
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