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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Piotrowska, Katarzyna | - |
dc.contributor.author | Borkowska, Sylwia J. | - |
dc.contributor.author | Wiszniewska, Barbara | - |
dc.contributor.author | Laszczyńska, Maria | - |
dc.contributor.author | Słuczanowska-Głąbowska, Sylwia | - |
dc.contributor.author | Havens, Aaron M. | - |
dc.contributor.author | Kopchick, John J. | - |
dc.contributor.author | Bartke, Andrzej | - |
dc.contributor.author | Taichman, Russel S. | - |
dc.contributor.author | Kucia, Magda | - |
dc.contributor.author | Ratajczak, Mariusz Z. | - |
dc.date.accessioned | 2018-09-10T14:49:14Z | - |
dc.date.available | 2018-09-10T14:49:14Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Histology and Histopathology, vol. 28, nº 10 (2013) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/60959 | - |
dc.description.abstract | It is well known that somatotrophic/insulin signaling affects lifespan in experimental animals. To study the effects of insulin-like growth factor-1 (IGF-1) plasma level on the morphology of major organs, we analyzed lung, heart, liver, kidney, bone marrow, and spleen isolated from 2-year-old growth hormone receptor knockout (GHR-KO) Laron dwarf mice (with low circulating plasma levels of IGF-1) and 6-month-old bovine growth hormone transgenic (bGHTg) mice (with high circulating plasma levels of IGF-1). The ages of the two mutant strains employed in our studies were selected based on their overall ~50% survival (Laron dwarf mice live up to ~4 years and bGHTg mice up to ~1 year). Morphological analysis of the organs of long-living 2-year-old Laron dwarf mice revealed a lower biological age for their organs compared with normal littermates, with more brown adipose tissue (BAT) surrounding the main body organs, lower levels of steatosis in liver, and a lower incidence of leukocyte infiltration in different organs. By contrast, the organs of 6-month-old, short-living bGHTg mice displayed several abnormalities in liver and kidney and a reduced content of BAT around vital organs. | es |
dc.format | application/pdf | es |
dc.format.extent | 12 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Aging | es |
dc.subject | Brown adipose tissue | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología | es |
dc.title | The effect of low and high plasma levels of insulin-like growth factor-1 (IGF-1) on the morphology of major organs: studies of Laron dwarf and bovine growth hormone transgenic (bGHTg) mice | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.28, nº10 (2013) |
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Piotrowska-28-1325-1336-2013.pdf | 21,8 MB | Adobe PDF | Visualizar/Abrir |
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