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Título: The level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast cancer
Fecha de publicación: 2013
Editorial: F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
Cita bibliográfica: Histology and histopathology, Vol. 28, n.º 5 (2013)
ISSN: 0213-3911
1699-5848
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Palabras clave: pAkt
CerbB2
Resumen: Although some evidence has been documented on EGFR/PI3K mediation of Akt activation in breast cancers, ILK and DNA-PK have not been investigated so far. The aim of this study was to analyze the expression of phosphorylated Akt (pAkt) in breast cancer, with respect to its upstream regulators. The immunostaining of pAkt (Ser473) in 70 invasive breast cancers revealed that status of CerbB2 could play a major role in Akt phosphorylation, while ILK was also involved in the stimulated level of pAkt. The results would provide an important clue for the activation of Akt and potential targeted therapy in breast cancer.
Autor/es principal/es: Chi, Yingkai
Zhao, Jing
Cui, Su-Ping
Jiang, Ping
Wang, Jian-ping
Zhang, Hong
Mao, Jing-Zhuo
Liu, Hai-Jing Liu
Hou, Lin
Zhang, Bo
URI: http://hdl.handle.net/10201/58339
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 7
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.28, nº 5 (2013)

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