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dc.contributor.authorChi, Yingkai-
dc.contributor.authorZhao, Jing-
dc.contributor.authorCui, Su-Ping-
dc.contributor.authorJiang, Ping-
dc.contributor.authorWang, Jian-ping-
dc.contributor.authorZhang, Hong-
dc.contributor.authorMao, Jing-Zhuo-
dc.contributor.authorLiu, Hai-Jing Liu-
dc.contributor.authorHou, Lin-
dc.contributor.authorZhang, Bo-
dc.identifier.citationHistology and histopathology, Vol. 28, n.º 5 (2013)es_ES
dc.description.abstractAlthough some evidence has been documented on EGFR/PI3K mediation of Akt activation in breast cancers, ILK and DNA-PK have not been investigated so far. The aim of this study was to analyze the expression of phosphorylated Akt (pAkt) in breast cancer, with respect to its upstream regulators. The immunostaining of pAkt (Ser473) in 70 invasive breast cancers revealed that status of CerbB2 could play a major role in Akt phosphorylation, while ILK was also involved in the stimulated level of pAkt. The results would provide an important clue for the activation of Akt and potential targeted therapy in breast cancer.es_ES
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes_ES
dc.titleThe level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast canceres_ES
Appears in Collections:Vol.28, nº 5 (2013)

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