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Title: The level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast cancer
Issue Date: 2013
Publisher: F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
Citation: Histology and histopathology, Vol. 28, n.º 5 (2013)
ISSN: 0213-3911
Related subjects: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Keywords: pAkt
Abstract: Although some evidence has been documented on EGFR/PI3K mediation of Akt activation in breast cancers, ILK and DNA-PK have not been investigated so far. The aim of this study was to analyze the expression of phosphorylated Akt (pAkt) in breast cancer, with respect to its upstream regulators. The immunostaining of pAkt (Ser473) in 70 invasive breast cancers revealed that status of CerbB2 could play a major role in Akt phosphorylation, while ILK was also involved in the stimulated level of pAkt. The results would provide an important clue for the activation of Akt and potential targeted therapy in breast cancer.
Primary author: Chi, Yingkai
Zhao, Jing
Cui, Su-Ping
Jiang, Ping
Wang, Jian-ping
Zhang, Hong
Mao, Jing-Zhuo
Liu, Hai-Jing Liu
Hou, Lin
Zhang, Bo
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 7
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.28, nº 5 (2013)

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