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Título: | Expression of cyclooxygenase-2 in invasive breast carcinomas and its prognostic impact |
Fecha de publicación: | 2012 |
Editorial: | F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and histopathology, Vol. 27, nº 10 (2012) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales::57 - Biología |
Palabras clave: | Breast cancer |
Resumen: | Representative tumour sections from 468 patients with invasive breast cancer were immunostained for cyclooxygenase-2 (COX-2) and evaluated. The relationships between COX-2 expression, clinical outcome and various clinicopathological variables, including tumour vascularity and disseminated tumour cells (DTC) in the bone marrow were examined. COX-2 expression in invasive breast carcinoma cells was positively associated with oestrogen receptor and/or progesterone receptor positivity (p<0.001). Triple-negative tumours showed no/low COX-2 expression more frequently than other tumour types (p<0.001). Expression of COX-2 was not associated with breast cancer-specific survival (p=0.49, log-rank) or distant disease-free survival (p=0.67, log-rank) for all patients, including lymph node-negative, untreated patients (p>0.14, log-rank). There was also no significant association between COX-2 expression and histological grade, tumour size, nodal status, DTC in bone marrow, p53, HER2, or tumour vascularity. In conclusion, COX-2 expression in this series was associated with the presence of hormone receptors. Low COX-2 expression was observed in triple-negative breast carcinomas. |
Autor/es principal/es: | Dhakal, Hari Prasad Naume, Bjørn Synnestvedt, Marit Borgen, Elin Kaaresen, Rolf Schlichting, Ellen Wiedswang, Gro Bassarova, A.V. Holm, Ruth Giercksky, Karl- Erik Nesland, Jahn M. |
URI: | http://hdl.handle.net/10201/54458 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 11 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.27, nº10 (2012) |
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Fichero | Descripción | Tamaño | Formato | |
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Dhakal-27-1315-1325-2012.pdf | 9,98 MB | Adobe PDF | Visualizar/Abrir |
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