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http://hdl.handle.net/10201/54458
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Dhakal, Hari Prasad | - |
dc.contributor.author | Naume, Bjørn | - |
dc.contributor.author | Synnestvedt, Marit | - |
dc.contributor.author | Borgen, Elin | - |
dc.contributor.author | Kaaresen, Rolf | - |
dc.contributor.author | Schlichting, Ellen | - |
dc.contributor.author | Wiedswang, Gro | - |
dc.contributor.author | Bassarova, A.V. | - |
dc.contributor.author | Holm, Ruth | - |
dc.contributor.author | Giercksky, Karl- Erik | - |
dc.contributor.author | Nesland, Jahn M. | - |
dc.date.accessioned | 2017-11-08T15:45:44Z | - |
dc.date.available | 2017-11-08T15:45:44Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Histology and histopathology, Vol. 27, nº 10 (2012) | es |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.uri | http://hdl.handle.net/10201/54458 | - |
dc.description.abstract | Representative tumour sections from 468 patients with invasive breast cancer were immunostained for cyclooxygenase-2 (COX-2) and evaluated. The relationships between COX-2 expression, clinical outcome and various clinicopathological variables, including tumour vascularity and disseminated tumour cells (DTC) in the bone marrow were examined. COX-2 expression in invasive breast carcinoma cells was positively associated with oestrogen receptor and/or progesterone receptor positivity (p<0.001). Triple-negative tumours showed no/low COX-2 expression more frequently than other tumour types (p<0.001). Expression of COX-2 was not associated with breast cancer-specific survival (p=0.49, log-rank) or distant disease-free survival (p=0.67, log-rank) for all patients, including lymph node-negative, untreated patients (p>0.14, log-rank). There was also no significant association between COX-2 expression and histological grade, tumour size, nodal status, DTC in bone marrow, p53, HER2, or tumour vascularity. In conclusion, COX-2 expression in this series was associated with the presence of hormone receptors. Low COX-2 expression was observed in triple-negative breast carcinomas. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Breast cancer | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología | es |
dc.title | Expression of cyclooxygenase-2 in invasive breast carcinomas and its prognostic impact | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.27, nº10 (2012) |
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Dhakal-27-1315-1325-2012.pdf | 9,98 MB | Adobe PDF | ![]() Visualizar/Abrir |
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