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Título: | Molecular characterization of EGFR and EGFR-downstream pathways in triple negative breast carcinomas with basal like features |
Fecha de publicación: | 2012 |
Editorial: | F. Hernandez y JuanF. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología. |
Cita bibliográfica: | Histology and Histopatholy, Volume 27, number 6 (June), 2012 |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales::57 - Biología |
Palabras clave: | Triple negative Breast cancer |
Resumen: | Aims: Triple negative breast cancer with basal like features (TN-BCBL) do not benefit from hormonal and anti-HER2 therapies. As a considerable fraction of TN-BCBLs shows EGFR deregulation, EGFR-targeted therapies have been proposed as an option. The characterization of EGFR and EGFR-downstream members may therefore provide important predictive information. Methods and results: Based on morphological and immunophenotypic features, we identified 38 TN-BCBLs that were subsequently investigated for alterations in EGFR signaling pathways. EGFR and PTEN protein levels were studied by immunohistochemistry, EGFR gene status by FISH, EGFR, H-Ras, K-Ras, N-Ras, BRAF and PIK3CA gene mutations by direct sequencing. EGFR overexpression and loss of PTEN expression characterized the majority of TN-BCBLs (76% and 74% of patients, respectively). EGFR gene copy number gain (FISH+) was identified in 51% of analyzable patients. PIK3CA gene mutations were detected in three cases (8%), whereas EGFR, H-Ras, K-Ras, N-Ras and BRAF genes showed no mutations. Overall, out of 17 patients classified as FISH+, 12 cases (70%) showed a concomitant alteration in PI3K/PTEN pathway. Conclusions: These results provide evidence that the efficacy of anti-EGFR drugs in TN-BCBL patients could be impaired by frequent alterations in the PI3K/PTEN axis, and suggest that TN-BCBLs could benefit from tailored treatments against this axis. |
Autor/es principal/es: | Martin, Vittoria Botta, Francesca Zanellato, Elena Molinari, Francesca Crippa, Stefano Mazzucchelli, Luca Frattini, Milo |
URI: | http://hdl.handle.net/10201/52457 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.27, nº 6 (2012) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Martin-27-785-792-2012.pdf | 3,96 MB | Adobe PDF | Visualizar/Abrir |
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