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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Martin, Vittoria | - |
dc.contributor.author | Botta, Francesca | - |
dc.contributor.author | Zanellato, Elena | - |
dc.contributor.author | Molinari, Francesca | - |
dc.contributor.author | Crippa, Stefano | - |
dc.contributor.author | Mazzucchelli, Luca | - |
dc.contributor.author | Frattini, Milo | - |
dc.date.accessioned | 2017-03-13T15:57:08Z | - |
dc.date.available | 2017-03-13T15:57:08Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Histology and Histopatholy, Volume 27, number 6 (June), 2012 | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/52457 | - |
dc.description.abstract | Aims: Triple negative breast cancer with basal like features (TN-BCBL) do not benefit from hormonal and anti-HER2 therapies. As a considerable fraction of TN-BCBLs shows EGFR deregulation, EGFR-targeted therapies have been proposed as an option. The characterization of EGFR and EGFR-downstream members may therefore provide important predictive information. Methods and results: Based on morphological and immunophenotypic features, we identified 38 TN-BCBLs that were subsequently investigated for alterations in EGFR signaling pathways. EGFR and PTEN protein levels were studied by immunohistochemistry, EGFR gene status by FISH, EGFR, H-Ras, K-Ras, N-Ras, BRAF and PIK3CA gene mutations by direct sequencing. EGFR overexpression and loss of PTEN expression characterized the majority of TN-BCBLs (76% and 74% of patients, respectively). EGFR gene copy number gain (FISH+) was identified in 51% of analyzable patients. PIK3CA gene mutations were detected in three cases (8%), whereas EGFR, H-Ras, K-Ras, N-Ras and BRAF genes showed no mutations. Overall, out of 17 patients classified as FISH+, 12 cases (70%) showed a concomitant alteration in PI3K/PTEN pathway. Conclusions: These results provide evidence that the efficacy of anti-EGFR drugs in TN-BCBL patients could be impaired by frequent alterations in the PI3K/PTEN axis, and suggest that TN-BCBLs could benefit from tailored treatments against this axis. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | F. Hernandez y JuanF. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología. | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Triple negative | es |
dc.subject | Breast cancer | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología | es |
dc.title | Molecular characterization of EGFR and EGFR-downstream pathways in triple negative breast carcinomas with basal like features | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.27, nº 6 (2012) |
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Martin-27-785-792-2012.pdf | 3,96 MB | Adobe PDF | Visualizar/Abrir |
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