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Title: Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys
Issue Date: 2012
Publisher: F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
Citation: Histology and histopathology, Vol. 27, nº 1 (2012)
ISSN: 1699-5848
Related subjects: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.8 - Neurología. Neuropatología. Sistema nervioso
Keywords: Parkinson´s disease
Abstract: In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of chronic parkinsonian macaques, characterized by the expression of c-Fos, which correlated with dopaminergic degeneration. These results are compatible with the results observed in fMRI in Parkinson’s disease patients, and may contribute to the understanding of additional alterations in the brain circuitry in Parkinsonism
Primary author: Heman, Paola
Barcia, Carlos
Gómez, Aurora
Ros, Carmen M.
Ros Bernal, Francisco
Yuste Jiménez, José Enrique
Pablos, Vicente de
Fernandez Villalba, Emiliano
Toledo Cárdenas, María Rebeca
Herrero Ezquerro, María Trinidad
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 6
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.27, nº 1 (2012)

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