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Título: | Lymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gastrointestinal stromal tumours |
Fecha de publicación: | 2011 |
Editorial: | F. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología. |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | 616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Gastrointestinal stromal tumor KIT |
Resumen: | This study aimed to assess the distribution of VEGF-C and VEGFR-3 expression in gastrointestinal stromal tumours (GISTs), and to analyse the value of lymphatic vessel density (LVD) in a tumour that is believed to preferentially metastasize through blood vessel conduits. A panel of immunohistochemical antibodies was used to evaluate 51 cases of genetically characterised GISTs: VEGF-C, VEGFR-3, D2-40 (for LVD assessment) and CD31 (for blood vessel density – BDV – assessment). The results were correlated with the clinical-pathological data. The large majority of cases (86.2%; 44/51) showed a mutation of the KIT gene, most of them (72.5%; 37/51) revealing mutations in exon 11. VEGFR-3 was predominantly expressed in KIT mutated GISTs (p=0.019). High LVD was correlated with the absence of metastasis (p=0.010) and high BVD showed a positive correlation with the occurrence of metastasis (p=0.049). The strong expression of VEGF-C and VEGFR-3 in GIST’s cells was not correlated with the clinical parameters of aggressiveness, nor with high LVD. |
Autor/es principal/es: | Torres de Oliveira, Antônio Talvane Reis, Rui M. Alfonso, Julieta Martinho, Olga Matos, Delcio Lopes Carvalho, André Buosi Silva, Thiago Scapulatempo, Cristovam Sydney Saad, Sarhan Longatto-Filho, Adhemar |
Forma parte de: | Histology and histopathology, Vol. 26, nº12 (2011) |
URI: | http://hdl.handle.net/10201/49526 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.26,nº12 (2011) |
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de-Oliveira-26-1499-1507-2011.pdf | 1,51 MB | Adobe PDF | Visualizar/Abrir |
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