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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Torres de Oliveira, Antônio Talvane | - |
dc.contributor.author | Reis, Rui M. | - |
dc.contributor.author | Alfonso, Julieta | - |
dc.contributor.author | Martinho, Olga | - |
dc.contributor.author | Matos, Delcio | - |
dc.contributor.author | Lopes Carvalho, André | - |
dc.contributor.author | Buosi Silva, Thiago | - |
dc.contributor.author | Scapulatempo, Cristovam | - |
dc.contributor.author | Sydney Saad, Sarhan | - |
dc.contributor.author | Longatto-Filho, Adhemar | - |
dc.date.accessioned | 2016-05-03T14:51:03Z | - |
dc.date.available | 2016-05-03T14:51:03Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/49526 | - |
dc.description.abstract | This study aimed to assess the distribution of VEGF-C and VEGFR-3 expression in gastrointestinal stromal tumours (GISTs), and to analyse the value of lymphatic vessel density (LVD) in a tumour that is believed to preferentially metastasize through blood vessel conduits. A panel of immunohistochemical antibodies was used to evaluate 51 cases of genetically characterised GISTs: VEGF-C, VEGFR-3, D2-40 (for LVD assessment) and CD31 (for blood vessel density – BDV – assessment). The results were correlated with the clinical-pathological data. The large majority of cases (86.2%; 44/51) showed a mutation of the KIT gene, most of them (72.5%; 37/51) revealing mutations in exon 11. VEGFR-3 was predominantly expressed in KIT mutated GISTs (p=0.019). High LVD was correlated with the absence of metastasis (p=0.010) and high BVD showed a positive correlation with the occurrence of metastasis (p=0.049). The strong expression of VEGF-C and VEGFR-3 in GIST’s cells was not correlated with the clinical parameters of aggressiveness, nor with high LVD. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología. | es |
dc.relation.ispartof | Histology and histopathology, Vol. 26, nº12 (2011) | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Gastrointestinal stromal tumor | es |
dc.subject | KIT | es |
dc.subject.other | 616 - Patología. Medicina clínica. Oncología | es |
dc.title | Lymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gastrointestinal stromal tumours | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.26,nº12 (2011) |
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de-Oliveira-26-1499-1507-2011.pdf | 1,51 MB | Adobe PDF | Visualizar/Abrir |
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