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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Mylonas, Ioannis | - |
dc.date.accessioned | 2016-05-02T17:12:23Z | - |
dc.date.available | 2016-05-02T17:12:23Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/49501 | - |
dc.description.abstract | Inhibins, dimeric peptide hormones composed of an alpha-subunit and one of two possible beta-subunits (betaA or betaB), exhibit substantial roles in human reproduction and in endocrine-responsive tumours. However, the prognostic significance and clinical implications of the inhibin-betaB subunit in uterine endometrioid adenocarcinomas is still not defined yet. A series of 227 uterine endometrioid adenocarcinomas of a previous well-characterized cohort were re-evaluated for the expression of the inhibin-betaB subunit and correlated with several clinicopathological characteristics and the clinical outcome. In this re-analysis, the betaB-subunit expression demonstrated a significant association with the patients' age and cervical involvement. However, inhibin-betaB did not significantly affect the patients survival in this large cohort group. However, patients with a higher intensity of betaB-subunit immunolabelling had a slightly worse survival expectation, although without any significant association, suggesting that this subunit might have a substantial role in the carcinogenesis and pathology of endometrioid adenocarcinomas. Thus, the inhibin-betaB subunit appears not to be a useful prognostic marker regarding endometrioid adenocarcinomas. However, further research is warranted in elucidating the possible implications of inhibin-ßB and endometrial carcinogenesis. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología. | es |
dc.relation.ispartof | Histology and histopathology, Vol. 26, nº11 (2011) | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Endometrial cancer | es |
dc.subject | Endometrioid adenocarcinomas | es |
dc.subject.other | 618 - Ginecología. Obstetricia | es |
dc.title | Inhibin beta B: a useful tumor marker in uterine endometrioid adenocarcinomas? | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.26,nº11 (2011) |
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Mylonas-26-1415-1422-2011.pdf | 893,71 kB | Adobe PDF | Visualizar/Abrir |
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