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Título: | Transglutaminase 2 expression is significantly increased in cyclosporine-induced gingival overgrowth |
Fecha de publicación: | 2011 |
Editorial: | F. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología. |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | 616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Transglutaminase 2 Cyclosporine |
Resumen: | Cyclosporine A is a potent immunosuppressant used to prevent organ transplant rejection and treat various autoimmune diseases. However, cyclosporine A can also induce gingival overgrowth, which is characterized by increased extracellular matrix due to an altered balance between collagen synthesis and degradation. This study proposed to verify whether trans-glutaminase 2, an enzyme thought to be responsible for the assembly and remodelling of extracellular matrix, plays any role in the pathogenesis of cyclosporine A-induced gingival overgrowth. Cyclosporine A-induced gingival overgrowths were collected from 21 liver transplant patients and case-controlled with 20 non-hyperplastic gingival biopsies from healthy patients who had previous periodontal treatment. In both groups, the presence and tissue distribution of transglutaminase 2 were determined by immunohistochemistry and analyzed in comparison with the tissue morphology and expression of lymphocyte-related antigens (CD3 and CD20) and a vessel-related marker (CD34). Transglutaminase 2 expression showed a significant increase (2.6-fold) in the stromal component of cyclosporine A-treated patients compared with controls (p<0.001), which suggested that transglutaminase 2 had a role in the pathogenesis of the disease. Further studies should investigate the therapeutic effect of anti-transglutaminase 2 drugs (putrescine or 1,4-diamino-butane) in these patients. |
Autor/es principal/es: | Asioli, Sofia Righi, Alberto Cardone, Pietro Aimetti, Mario Maletta, Francesca Coda, Renato Carossa, Stefano Navone, Roberto Cassoni, Paola |
Forma parte de: | Histology and histopathology, Vol. 26, nº11 (2011) |
URI: | http://hdl.handle.net/10201/49496 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.26,nº11 (2011) |
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Asioli-26-1399-1404-2011.pdf | 532 kB | Adobe PDF | Visualizar/Abrir |
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